{"id":598,"date":"2026-10-25T12:13:32","date_gmt":"2026-10-25T11:13:32","guid":{"rendered":"https:\/\/purvival.com\/journal\/?post_type=bw_ingredient&p=598"},"modified":"2026-10-25T22:28:21","modified_gmt":"2026-10-25T21:28:21","slug":"chardon-marie","status":"publish","type":"bw_ingredient","link":"https:\/\/purvival.com\/journal\/ingredients\/chardon-marie\/","title":{"rendered":"Chardon marie"},"content":{"rendered":"

Ce que c\u2019est<\/h2>\n

Le chardon-Marie (Silybum marianum<\/em>) est un grand chardon du pourtour m\u00e9diterran\u00e9en, de la m\u00eame famille que l\u2019artichaut, reconnaissable \u00e0 ses feuilles vein\u00e9es de blanc. On en utilise les fruits, souvent appel\u00e9s graines. Ils contiennent de la silymarine, un m\u00e9lange de six flavonolignanes principaux et d\u2019autres polyph\u00e9nols<\/a>.<\/p>\n

L\u2019Agence europ\u00e9enne des m\u00e9dicaments<\/a> reconna\u00eet l\u2019usage traditionnel de ces fruits chez l\u2019adulte pour soulager les troubles digestifs, comme la sensation de lourdeur et la digestion difficile, et pour soutenir le fonctionnement du foie, une fois qu\u2019un m\u00e9decin a \u00e9cart\u00e9 une maladie s\u00e9rieuse.<\/p>\n

Int\u00e9grale D\u00e9tox contient un extrait sec de graine de chardon-Marie, dans son complexe D\u00e9tox & Sant\u00e9 du foie, avec du radis noir, de l\u2019artichaut et du desmodium.<\/p>\n","protected":false},"excerpt":{"rendered":"

Grand chardon m\u00e9diterran\u00e9en, cousin de l\u2019artichaut, dont on utilise les fruits pour la digestion et le foie.<\/p>\n","protected":false},"featured_media":2732,"template":"","meta":{"_bw_latin":"Silybum marianum","_bw_synonyms":"chardon-Marie, silymarine","_bw_brand":"","_bw_precautions":"","_bw_subtitle":"","_bw_studies_intro":"

Chez 99 adultes atteints de st\u00e9atoh\u00e9patite non alcoolique, 700 mg de silymarine trois fois par jour pendant 48 semaines ont fait reculer la fibrose du foie d\u2019au moins un stade chez 22 % des patients, contre 6 % sous placebo (Wah Kheong et al., 2017<\/a>). Une revue d\u2019\u00e9tudes cliniques chez des patients atteints de maladies du foie conclut que la silymarine a prot\u00e9g\u00e9 le foie et a \u00e9t\u00e9 tr\u00e8s bien tol\u00e9r\u00e9e (Gillessen et al., 2020<\/a>). Dans la st\u00e9atose h\u00e9patique m\u00e9tabolique, une revue Cochrane de 17 essais associe la silymarine seule \u00e0 une baisse de l\u2019ALT de 7,21 U\/L en moyenne (Wang et al., 2025<\/a>).<\/p>","_bw_mention":"","_bw_studies":[{"resultat":"La fibrose du foie a recul\u00e9 d\u2019au moins un stade chez 22 % des patients sous silymarine, contre 6 % sous placebo.","type":"essai","population":"99 adultes atteints de st\u00e9atoh\u00e9patite non alcoolique (NASH)","dose":"700 mg de silymarine trois fois par jour","duree":"48 semaines","auteurs":"Wah Kheong et al.","annee":"2017","revue":"Clinical Gastroenterology and Hepatology","lien":"https:\/\/doi.org\/10.1016\/j.cgh.2017.04.016","source":"publication","note":"R\u00e9sum\u00e9 PubMed 28419855 lu. Crit\u00e8re principal non atteint, dit tel quel ; fibrose en crit\u00e8re secondaire."},{"resultat":"Dans les \u00e9tudes chez des patients atteints de maladie du foie li\u00e9e \u00e0 l\u2019alcool ou de st\u00e9atose (foie gras), cirrhose comprise, la silymarine a prot\u00e9g\u00e9 le foie et a \u00e9t\u00e9 tr\u00e8s bien tol\u00e9r\u00e9e.","type":"revue","population":"\u00c9tudes cliniques chez des patients atteints de maladies du foie","dose":"","duree":"","auteurs":"Gillessen et Schmidt","annee":"2020","revue":"Advances in Therapy","lien":"https:\/\/doi.org\/10.1007\/s12325-020-01251-y","source":"publication","note":"Revue narrative (PubMed 32065376), centr\u00e9e sur la formule Eurosil 85\u00ae ; pas une m\u00e9ta-analyse."},{"resultat":"Dans la st\u00e9atose h\u00e9patique m\u00e9tabolique, la silymarine seule a \u00e9t\u00e9 associ\u00e9e \u00e0 une baisse de l\u2019ALT de 7,21 U\/L (6 essais, 409 participants) et de la GGT de 8,30 U\/L (1 essai) par rapport \u00e0 l\u2019absence de traitement ou au placebo.","type":"revue","population":"17 essais randomis\u00e9s, 2 069 adultes ayant une st\u00e9atose h\u00e9patique m\u00e9tabolique","dose":"","duree":"4 \u00e0 48 semaines","auteurs":"Wang et al.","annee":"2025","revue":"Cochrane Database of Systematic Reviews","lien":"https:\/\/doi.org\/10.1002\/14651858.CD015524.pub2","source":"publication","note":"R\u00e9sum\u00e9 PubMed 40552569 lu. Pas de baisse des enzymes du foie avec la silymarine associ\u00e9e \u00e0 des excipients (silymarin complex) ni face \u00e0 d\u2019autres traitements ; certitude faible \u00e0 tr\u00e8s faible, essais souvent \u00e0 risque de biais."}],"_bw_documents":[],"_bw_claims":["Soutient la sant\u00e9 du foie","Utile pour maintenir les fonctions physiologiques de purification","Aide \u00e0 l'\u00e9quilibre des sucres physiologiques"],"_bw_logo":0,"_bw_logo_dark":false},"class_list":["post-598","bw_ingredient","type-bw_ingredient","status-publish","has-post-thumbnail","hentry"],"yoast_head":"\nChardon marie - Journal Purvival<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/purvival.com\/journal\/ingredients\/chardon-marie\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chardon marie - 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